与枯草芽孢杆菌的一段“恋情”。
A love affair with Bacillus subtilis.
作者信息
Losick Richard
机构信息
From the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 01238
出版信息
J Biol Chem. 2015 Jan 30;290(5):2529-38. doi: 10.1074/jbc.X114.634808. Epub 2014 Dec 22.
Abstract
My career in science was launched when I was an undergraduate at Princeton University and reinforced by graduate training at the Massachusetts Institute of Technology. However, it was only after I moved to Harvard University as a junior fellow that my affections were captured by a seemingly mundane soil bacterium. What Bacillus subtilis offered was endless fascinating biological problems (alternative sigma factors, sporulation, swarming, biofilm formation, stochastic cell fate switching) embedded in a uniquely powerful genetic system. Along the way, my career in science became inseparably interwoven with teaching and mentoring, which proved to be as rewarding as the thrill of discovery.
摘要
我的科学职业生涯始于我在普林斯顿大学读本科时，并在麻省理工学院的研究生训练中得到强化。然而，直到我作为初级研究员搬到哈佛大学后，我才被一种看似普通的土壤细菌所吸引。枯草芽孢杆菌带来的是无穷无尽的迷人生物学问题（替代西格玛因子、孢子形成、群体运动、生物膜形成、随机细胞命运转换），这些问题嵌入在一个独特强大的遗传系统中。一路走来，我的科学职业生涯与教学和指导密不可分地交织在一起，事实证明，这与发现的兴奋感一样有意义。
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