Tang X F
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1989 Feb;22(1):17-9, 61.
Four of 69 cases of small cell lung cancer (SCLC) showed evidence of Lambert-Eaton myasthenic Syndrome (LEMS) were studied neurologically and neurophysiologically in four years. The LEMS appearance were preceded that of SCLC in 3 cases for two years at most. Repeated stimulation of ulnar nerve examination showed diminished amplitude of initial response (0.2-0.9 mv); Amplitude of the response at 3 c/s stimulation for 3 sec was diminished 20-63%. (control 3% decreases-13% increases) but that at 20 c/s stimulation for 10 sec increased 200-800% increases. (control: 20% decreases-56% increases). These findings were important for diagnosis of LEMS. The abnormalities of neurotransmission seems to be due to inadequate release of acetyl choline from nerve terminals at abnormal active zone of Ca++ channels.
在四年时间里，对69例小细胞肺癌（SCLC）患者中出现兰伯特 - 伊顿肌无力综合征（LEMS）迹象的4例患者进行了神经学和神经生理学研究。3例患者中LEMS症状先于SCLC出现，最长提前两年。对尺神经进行反复刺激检查显示，初始反应幅度减小（0.2 - 0.9毫伏）；3赫兹刺激3秒时反应幅度减小20% - 63%（对照组降低3% - 升高13%），但20赫兹刺激10秒时反应幅度升高200% - 800%（对照组：降低20% - 升高56%）。这些发现对LEMS的诊断很重要。神经传递异常似乎是由于钙离子通道异常活跃区神经末梢乙酰胆碱释放不足所致。
