[Relationship between cyclic nucleotide phosphodiesterases (cPDE) and some patho-biologic behaviors of stomach cancer--I. Histochemical studies of CPDE in stomach cancer tissues].

Distributions and activities of both cyclic adenosine 3',5'-monophosphate phosphodiesterase and cyclic guanosine 3',5'-monophosphate phosphodiesterase (cAMP-PDE and cGMP-PDE) in 43 human stomach cancer tissues were studied histochemically. The relationship between cyclic nucleotide phosphodiesterases and some patho-biologic behaviors of stomach cancer was preliminarily discussed, and so was the application of these two enzymes in clinical practice of gastric cancers. The Results showed that the two cyclic nucleotide phosphodiesterases were closely correlated with some patho-biologic behaviors of stomach cancer. The authors considered that the histochemical investigation of cyclic nucleotide phosphodiesterases in stomach cancer tissues can be useful in determining the malignant degree and estimating the prognosis of stomach cancer objectively.