[Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone].

The effects of a semisynthetic diterpene sclareol glycol (SG) on the release of adenohypophysial hormones prolactin, somatotrophic hormone (STH) and adrenocorticotrophic hormone (ACTH) were studied in the plasma of the rat. The effects of SG were investigated also parallel with diterpene forskolin (F) on the release of prolactin and STH in tissue cultures of adenohypophysial cells of the rat. The experiments established that SG increased in a low dose, but in higher dose lowered the concentration of plasma prolactin and STH. These effects were found even after 15 minutes after its intraperitoneal administration. SG induced mainly an increase of plasma concentration of ACTH. In tissue cultures of adenohypophysial cells SG caused lowering of prolactin concentration and an increase of STH; under these conditions F caused only an increase in the concentration of these hormones. The results show that SG influences secretion of prolactin, STH and ACTH in various ways in comparison with F. This might be due to th their various chemical structure and to their basic mechanisms of action (mainly by 3',5'-AMP for P; besides 3, 5'-AMP substantial participation of DA-ergic and GABA-ergic mediation for SG).