Copês Rafaela Martinez, Comim Fabio Vasconcellos, Langer Felipe Welter, Codevilla Antonio Aurelio da Silveira, Sartori Giovani Ruviaro, de Oliveira Cristina, Cocco Aline Rubin, de Almeida Adriana Maria, de Almeida Luciana Leiria, Dal Osto Léo Canterle, Compston Juliet Elizabeth, Premaor Melissa Orlandin
Pós-graduação em Ciências da Saúde, Federal University of Santa Maria, Santa Maria, Brazil; Grupo de Pesquisas em Doenças Osteometabólicas Crônicas, Departamento de Clínica Médica, Federal University of Santa Maria, Santa Maria, Brazil.
Grupo de Pesquisas em Doenças Osteometabólicas Crônicas, Departamento de Clínica Médica, Federal University of Santa Maria, Santa Maria, Brazil.
J Clin Densitom. 2015 Apr-Jun;18(2):165-71. doi: 10.1016/j.jocd.2014.09.005. Epub 2014 Dec 17.
Obesity and osteoporosis are chronic disorders with increasing prevalence worldwide. The aim of this study was to investigate the association between obesity and fracture in postmenopausal women from Santa Maria, Brazil. A cross-sectional study was carried out at Santa Maria (parallel 29° south), Brazil. Postmenopausal women aged ≥55 yr who had at least 1 appointment at the primary care in the 2 years before the study were recruited from March 1, 2013 to August 31, 2013. The Global Longitudinal Study of Osteoporosis in Women study questionnaire was applied with permission of The Center for Outcomes Research, University of Massachusetts Medical School. Height and weight were measured according to the World Health Organization protocol. Bone fractures (excluding hand, feet, and head) that occurred after the age of 45 yr were considered as the outcome. Overall, 1057 women completed the study, of whom 984 had body mass index measured. The mean (standard deviation) age and body mass index of the women included in the study were 67.1 (7.6) yr and 29.2 (5.5) kg/m(2), respectively. The prevalence of fractures in obese and nonobese women was similar (17.3% vs 16.0%); 41.4% of all fractures occurred in obese women. Obese postmenopausal women make a substantial contribution to the overall burden of prevalent fractures in this population. Our results provide further evidence in support of the concept that obesity is not protective against fracture.
肥胖和骨质疏松症是在全球范围内患病率不断上升的慢性疾病。本研究的目的是调查巴西圣玛丽亚市绝经后妇女肥胖与骨折之间的关联。在巴西圣玛丽亚市(南纬29°平行线处)开展了一项横断面研究。从2013年3月1日至2013年8月31日,招募了年龄≥55岁且在研究前两年内至少在初级保健机构就诊过1次的绝经后妇女。在获得马萨诸塞大学医学院结果研究中心许可后,应用了全球妇女骨质疏松症纵向研究调查问卷。按照世界卫生组织的方案测量身高和体重。将45岁以后发生的骨折(不包括手部、足部和头部骨折)视为研究结果。总体而言,1057名妇女完成了研究,其中984名测量了体重指数。纳入研究的妇女的平均(标准差)年龄和体重指数分别为67.1(7.6)岁和29.2(5.5)kg/m²。肥胖和非肥胖妇女的骨折患病率相似(分别为17.3%和16.0%);所有骨折中有41.4%发生在肥胖妇女中。肥胖的绝经后妇女对该人群中普遍存在的骨折总体负担有很大影响。我们的结果为肥胖不能预防骨折这一概念提供了进一步的证据支持。