Michler A, Erdö S L
Department of Anatomy, Georg August University, Göttingen, F.R.G.
Eur J Pharmacol. 1989 Aug 29;167(3):423-5. doi: 10.1016/0014-2999(89)90453-6.
The influence of gamma-aminobutyric acid (GABA) receptor agonists and antagonists on the intracellular concentration of inositol 1,4,5-triphosphate (IP3) was examined in neuronal cultures of embryonic chick tectum. GABA and selective agonists of its receptors were inactive, whereas phaclofen, a GABA-B receptor antagonist, increased IP3 levels in a concentration-dependent manner. This effect occurred at phaclofen concentrations much lower than those required to affect GABA-B receptors. It is concluded that phaclofen, in addition to its known effect at GABA-B receptors, is also active at an as-yet undefined site.
在鸡胚视顶盖神经元培养物中，研究了γ-氨基丁酸（GABA）受体激动剂和拮抗剂对肌醇1,4,5-三磷酸（IP3）细胞内浓度的影响。GABA及其受体的选择性激动剂无活性，而GABA-B受体拮抗剂巴氯芬则以浓度依赖的方式增加IP3水平。这种效应发生时巴氯芬的浓度远低于影响GABA-B受体所需的浓度。得出的结论是，巴氯芬除了对GABA-B受体有已知作用外，在一个尚未明确的位点也有活性。
