妊娠对精神类药物处方的影响：一项法国队列研究。
Impact of pregnancy on psychotropic medication prescription: a French cohort study.
作者信息
Apter Gisèle, Devouche Emmanuel, Becquemont Laurent
机构信息
Unité de recherche en psychiatrie et psychopathologie, Erasme, Paris, France - Université Paris Diderot, Paris, France.
Unité de recherche en psychiatrie et psychopathologie, Erasme, Paris, France - Université Paris Descartes, EA 4057, Paris, France.
出版信息
Therapie. 2015 May-Jun;70(3):251-7. doi: 10.2515/therapie/2014212. Epub 2014 Dec 24.
OBJECTIVES
To determine if and when prescription of psychotropic medication in women is modified by pregnancy.
METHOD
Psychotropic prescription of 87 213 pregnant women affiliated with the French General Health System was examined. Period of analyses lasted 17 months to cover 4 months before and after pregnancy. A comparable cohort of 87 213 non pregnant women constituted the control group.
RESULTS
More than half of pregnant women to whom a psychoactive drug was prescribed were novel users during all three trimesters and after delivery. Prevalence of psychotropic medication before pregnancy is comparable to that of non-pregnant women. Rate of psychotropic medication during the peripartum stayed high, even though it decreased by half during the first trimester, showing a "pregnancy impact effect".
CONCLUSIONS
Data show a dramatic impact of pregnancy. More information on specific patterns of prescription needs to be gained in order to establish decision-making models for psychotropic prescription during pregnancy.
目的
确定孕期是否以及何时会改变女性精神药物的处方。
方法
对隶属于法国全民健康系统的87213名孕妇的精神药物处方进行了检查。分析期持续17个月，涵盖孕期前后4个月。87213名非孕妇组成的可比队列作为对照组。
结果
在所有三个孕期及产后，超过半数服用精神活性药物的孕妇是新使用者。孕前精神药物的患病率与非孕妇相当。围产期精神药物使用率一直很高，尽管在孕早期下降了一半，显示出“妊娠影响效应”。
结论
数据显示孕期有显著影响。需要获取更多关于特定处方模式的信息，以便建立孕期精神药物处方的决策模型。
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