Lin Sung-Yen, Chen Chung-Hwan, Fu Yin-Chih, Huang Peng-Ju, Chang Je-Ken, Huang Hsuan-Ti
Department of Orthopaedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Orthopaedics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Orthopaedics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Arthroplasty. 2015 May;30(5):776-80. doi: 10.1016/j.arth.2014.12.001. Epub 2014 Dec 5.
The purpose of this study is to investigate the effect of preoperative intravenous (IV) and intraoperative topical administration of tranexamic acid (TXA) in total knee arthroplasty (TKA). A total of 120 patients were and randomly allocated to either topical group, combined group, or control group. The mean total blood loss was lower in the combined and topical groups (705 mL and 579 mL, respectively) in comparison with control group (949 mL, P < 0.001). There was a significant difference in transfusion rate among groups (P = 0.009). The postoperative hemoglobin drop and total drain amount were significantly less in the combined group compared to other groups. In conclusion, combining preoperative IV injection and topical administration of TXA can effectively reduce blood loss and transfusion rate.
本研究的目的是探讨术前静脉注射（IV）和术中局部应用氨甲环酸（TXA）在全膝关节置换术（TKA）中的效果。总共120例患者被随机分配至局部应用组、联合应用组或对照组。联合应用组和局部应用组的平均总失血量（分别为705 mL和579 mL）低于对照组（949 mL，P < 0.001）。各组之间的输血率存在显著差异（P = 0.009）。联合应用组术后血红蛋白下降和总引流量明显少于其他组。总之，术前静脉注射与局部应用TXA相结合可有效减少失血量和输血率。
