糖尿病患者的癌症风险：身体活动和肥胖会改变这种关联吗？来自挪威HUNT研究的前瞻性数据。

Cancer risk in people with diabetes: Does physical activity and adiposity modify the association? Prospective data from the HUNT Study, Norway.

作者信息

Moe Børge, Nilsen Tom Ivar Lund

机构信息

Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

J Diabetes Complications. 2015 Mar;29(2):176-9. doi: 10.1016/j.jdiacomp.2014.12.001. Epub 2014 Dec 5.

DOI:10.1016/j.jdiacomp.2014.12.001

PMID:25534878

Abstract

AIMS

To examine whether physical activity and adiposity modify the increased risk of cancer associated with diabetes.

METHODS

We prospectively examined the association of diabetes and risk of cancer among 73,726 persons stratified by physical activity and body mass index (BMI). Adjusted hazard ratios (HRs) with 95% confidence intervals (CI) were estimated from Cox regression.

RESULTS

During a median follow-up of 22.0 years, 9572 people were diagnosed with incident cancer. There was no clear association between diabetes and cancer risk in those reporting high levels of physical activity (≥2.0h per week) (HR 0.93; 95% CI: 0.70-1.24) or those with a normal weight (BMI <25kg/m²) (HR 1.02; 95% CI: 0.84-1.25). However, among people with diabetes who reported low levels of physical activity (<2.0h per week), diabetes was associated with an HR of 1.15 (95% CI: 1.01-1.31). Correspondingly, diabetes was associated with an HR of 1.21 (95% CI: 1.07-1.37) among overweight or obese people (BMI ≥25kg/m²).

CONCLUSIONS

There was evidence that the increased risk of cancer associated with diabetes was confined to persons who reported low levels of physical activity, or who were overweight or obese.

摘要

目的

研究身体活动和肥胖是否会改变与糖尿病相关的癌症风险增加情况。

方法

我们前瞻性地研究了73726名按身体活动和体重指数（BMI）分层的人群中糖尿病与癌症风险的关联。通过Cox回归估计调整后的风险比（HR）及95%置信区间（CI）。

结果

在中位随访22.0年期间，9572人被诊断患有新发癌症。在报告高水平身体活动（每周≥2.0小时）的人群（HR 0.93；95% CI：0.70 - 1.24）或体重正常（BMI <25kg/m²）的人群（HR 1.02；95% CI：0.84 - 1.25）中，糖尿病与癌症风险之间没有明显关联。然而，在报告低水平身体活动（每周<2.0小时）的糖尿病患者中，糖尿病与HR为1.15（95% CI：1.01 - 1.31）相关。相应地，在超重或肥胖人群（BMI≥25kg/m²）中，糖尿病与HR为1.21（95% CI：1.07 - 1.37）相关。