Moe Børge, Nilsen Tom Ivar Lund
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
J Diabetes Complications. 2015 Mar;29(2):176-9. doi: 10.1016/j.jdiacomp.2014.12.001. Epub 2014 Dec 5.
To examine whether physical activity and adiposity modify the increased risk of cancer associated with diabetes.
We prospectively examined the association of diabetes and risk of cancer among 73,726 persons stratified by physical activity and body mass index (BMI). Adjusted hazard ratios (HRs) with 95% confidence intervals (CI) were estimated from Cox regression.
During a median follow-up of 22.0 years, 9572 people were diagnosed with incident cancer. There was no clear association between diabetes and cancer risk in those reporting high levels of physical activity (≥2.0h per week) (HR 0.93; 95% CI: 0.70-1.24) or those with a normal weight (BMI <25kg/m²) (HR 1.02; 95% CI: 0.84-1.25). However, among people with diabetes who reported low levels of physical activity (<2.0h per week), diabetes was associated with an HR of 1.15 (95% CI: 1.01-1.31). Correspondingly, diabetes was associated with an HR of 1.21 (95% CI: 1.07-1.37) among overweight or obese people (BMI ≥25kg/m²).
There was evidence that the increased risk of cancer associated with diabetes was confined to persons who reported low levels of physical activity, or who were overweight or obese.
研究身体活动和肥胖是否会改变与糖尿病相关的癌症风险增加情况。
我们前瞻性地研究了73726名按身体活动和体重指数（BMI）分层的人群中糖尿病与癌症风险的关联。通过Cox回归估计调整后的风险比（HR）及95%置信区间（CI）。
在中位随访22.0年期间，9572人被诊断患有新发癌症。在报告高水平身体活动（每周≥2.0小时）的人群（HR 0.93；95% CI：0.70 - 1.24）或体重正常（BMI <25kg/m²）的人群（HR 1.02；95% CI：0.84 - 1.25）中，糖尿病与癌症风险之间没有明显关联。然而，在报告低水平身体活动（每周<2.0小时）的糖尿病患者中，糖尿病与HR为1.15（95% CI：1.01 - 1.31）相关。相应地，在超重或肥胖人群（BMI≥25kg/m²）中，糖尿病与HR为1.21（95% CI：1.07 - 1.37）相关。
有证据表明，与糖尿病相关的癌症风险增加仅限于报告低水平身体活动的人群或超重或肥胖人群。
