Ovalle-Magallanes Berenice, Medina-Campos Omar N, Pedraza-Chaverri José, Mata Rachel
Facultad de Química, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico.
Facultad de Química, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico.
Phytochemistry. 2015 Feb;110:111-9. doi: 10.1016/j.phytochem.2014.11.004. Epub 2014 Dec 19.
An aqueous extract from the seeds of Swietenia humilis (31.6-100mg/kg bw) lowered (p<0.05) blood glucose levels in normal and nicotinamide-streptozotocin (NA-STZ)-induced hyperglycemic mice. Furthermore, when administered to fructose-fed rats with metabolic syndrome, the decoction showed significant antihyperglycemic, hypoglycemic and hypolipidemic effects, as well as an augmentation of hepatic glycogen. Limonoids 2-hydroxy-destigloyl-6-deoxyswietenine acetate (1), humulin B (2), methyl-2-hydroxy-3-β-isobutyroxy-1-oxomeliac-8(30)-enate (3), methyl-2-hydroxy-3-β-tigloyloxy-1-oxomeliac-8(30)-enate (4), humilinolide G (5), humilinolide C (6), methyl-2-hydroxy-3-β-isobutyoyl-8α,30α-epoxy-1-oxo-meliacate (7), and humilinolide H (8), were isolated from a CH2Cl2-MeOH (1:1) extract of the seeds. Compounds 5 and 8 are analogs of compounds 6 and 7. The structure of 5 was unequivocally established by X-ray analysis. When tested in normal and NA-STZ-hyperglycemic mice, compounds 1, 2, and 4 (3.16-31.6 mg/kg bw) decreased glycemia during an oral glucose tolerance test. The present investigation sustains the contemporary popular uses of S. humilis seeds for treating metabolic disorders, including diabetes and dyslipidemia and demonstrates the potential of the mexicanolides as antihyperglycemic agents.
洪都拉斯桃花心木种子的水提取物（31.6 - 100mg/kg体重）可降低正常小鼠和烟酰胺 - 链脲佐菌素（NA - STZ）诱导的高血糖小鼠的血糖水平（p<0.05）。此外，当给患有代谢综合征的果糖喂养大鼠服用时，该煎剂显示出显著的抗高血糖、降血糖和降血脂作用，以及肝糖原增加。从种子的二氯甲烷 - 甲醇（1:1）提取物中分离出柠檬苦素类化合物2 - 羟基 - 去乙酰基 - 6 - 脱氧斯韦特宁乙酸酯（1）、洪都拉斯桃花心木素B（2）、甲基 - 2 - 羟基 - 3 - β - 异丁酰氧基 - 1 - 氧代米列酸 - 8(30) - 烯酸酯（3）、甲基 - 2 - 羟基 - 3 - β - 惕各酰氧基 - 1 - 氧代米列酸 - 8(30) - 烯酸酯（4）、洪都拉斯桃花心木内酯G（5）、洪都拉斯桃花心木内酯C（6）、甲基 - 2 - 羟基 - 3 - β - 异丁酰基 - 8α,30α - 环氧 - 1 - 氧代米列酸酯（7）和洪都拉斯桃花心木内酯H（8）。化合物5和8是化合物6和7的类似物。化合物5的结构通过X射线分析明确确定。在正常小鼠和NA - STZ诱导的高血糖小鼠中进行测试时，化合物1、2和4（3.16 - 31.6mg/kg体重）在口服葡萄糖耐量试验期间降低了血糖水平。本研究支持了洪都拉斯桃花心木种子目前在治疗包括糖尿病和血脂异常在内的代谢紊乱方面的广泛应用，并证明了墨西哥内酯类化合物作为抗高血糖药物的潜力。
