Becker W, Börner W, Reiners C
Klinik und Poliklinik für Nuklearmedizin, Universität Würzburg, Germany.
Horm Metab Res Suppl. 1989;21:38-42.
In the follow-up of five patients with histologic proven medullary thyroid carcinoma (MTC) and raised serum calcitonin and CEA levels the pentavalent Tc-99m-(V)-DMSA and the Tc-99m-MDP bone scan had the highest sensitivity in the localisation of metastases. Both methods are not tumor specific. A false positive Tc-99m-(V)-DMSA uptake in an old osteomyelitis of one vertebra could be demonstrated. The J-123-MIBG and In-111-F(ab2)' antibody scan did not allow to localise one of the above described metastases. In conclusion in the follow-up of patients with MTC and elevated tumor marker concentrations the Tc-99m-(V)-DMSA and the Tc-99m-MDP bone scan should be the second diagnostic procedures after sonography has been performed.
在对5例经组织学证实的甲状腺髓样癌（MTC）且血清降钙素和癌胚抗原水平升高的患者进行随访时，五价锝-99m-（V）-二巯基丁二酸（DMSA）和锝-99m-亚甲基二膦酸盐（MDP）骨扫描在转移灶定位方面具有最高的敏感性。这两种方法都不是肿瘤特异性的。在一例椎体陈旧性骨髓炎中可显示出锝-99m-（V）-DMSA摄取出现假阳性。碘-123-间碘苄胍（MIBG）和铟-111-F（ab2）'抗体扫描无法对上述转移灶中的任何一个进行定位。总之，在对MTC且肿瘤标志物浓度升高的患者进行随访时，在已进行超声检查之后，锝-99m-（V）-DMSA和锝-99m-MDP骨扫描应作为第二项诊断程序。
