释放间充质趋化性。
Unleashing mesenchymal chemotaxis.
机构信息
Universidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain.
Universidad Autónoma de Madrid School of Medicine and Instituto de Investigación Sanitaria- Hospital Universitario de la Princesa (IIS-IP), Diego de León 62, 28006 Madrid, Spain.
出版信息
Dev Cell. 2014 Dec 22;31(6):669-70. doi: 10.1016/j.devcel.2014.12.005.
In this issue of Developmental Cell, Asokan and colleagues (2014) report that the phospholipase Cγ (PLCγ)-diacyl glycerol (DAG) protein kinase Cα (PKCα) signaling axis inhibits actomyosin bundling. This preferentially occurs at the leading edge of chemotactic mesenchymal cells via noncanonical phosphorylation of the regulatory light chain (RLC) of nonmuscle myosin II.
本期《发育细胞》中，Asokan 和同事（2014）报告称，磷酸脂酶 Cγ（PLCγ）-甘油二酯（DAG）蛋白激酶 Cα（PKCα）信号轴抑制肌动球蛋白束的形成。这主要通过非肌肉肌球蛋白 II 的调节轻链（RLC）的非典型磷酸化在趋化性间质细胞的前缘发生。
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