Zeng Yangmin, Magil Alex, Hussaini Trana, Yeung C Kit, Erb Siegfried R, Marquez-Alazagara Vladimir, Yoshida Eric M
Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Ann Hepatol. 2015 Jan-Feb;14(1):137-40.
Renal dysfunction frequently occurs in liver transplant recipients and is associated with increased morbidity and mortality. BK virus is a human polyoma virus that reactivates during immunocompromised states and is a known cause of renal allograft dysfunction in renal transplant recipients. However, BK nephropathy of native kidneys is rare in non-renal transplant recipients. There is no published data linking BK virus and renal dysfunction in liver transplant recipients. We describe the first confirmed case of native polyomavirus BK nephropathy in a liver transplant recipient. BK nephropathy should be considered in the differential diagnosis of new renal failure in liver transplant recipients.
肾功能障碍在肝移植受者中经常出现，且与发病率和死亡率的增加相关。BK病毒是一种人类多瘤病毒，在免疫功能低下状态下会重新激活，是肾移植受者肾移植功能障碍的已知病因。然而，在非肾移植受者中，天然肾脏的BK肾病很少见。目前尚无关于BK病毒与肝移植受者肾功能障碍之间关联的公开数据。我们描述了首例经证实的肝移植受者天然多瘤病毒BK肾病病例。在肝移植受者新发肾衰竭的鉴别诊断中应考虑BK肾病。
