Turk J Med Sci. 2014;44(2):279-82. doi: 10.3906/sag-1211-31.
To evaluate the usefulness of plasma glucose and serum cholinesterase levels as predictors of organophosphate-induced intermediate syndrome.
Seventy-one organophosphate poisoning patients who were admitted to our emergency department during a 4-year period were evaluated retrospectively. Four patients were excluded from the study due to a lack of medical records. Categorical variables were analyzed using the chi-square test and nonparametric variables were analyzed using the Mann-Whitney U test.
Thirty-five (52.2%) patients were male and 32(47.8%) were female. Patients had a mean age of 39.4 ± 15.9 years and 70.1% of the patients were married. Oral intake (68.7%) was the most common method of intoxication, and attempted suicide (67.2%) was the most common cause. The most common organophosphates were methamidophos (20.8%), dichlorvos (19.4%), parathion (7.5%), and methyl parathion (7.5%). Fifty-seven (85%) patients were treated in the emergency observation unit and 10 (15%) patients were admitted to the intensive care unit. Eleven (16%) patients developed intermediate syndrome and had significantly lower levels of serum cholinesterase (P < 0.01) and higher blood glucose levels (P = 0.037).
Initial serum cholinesterase and glucose levels measured in the emergency department may be a useful marker in predicting organophosphate-induced intermediate syndrome.
评估血浆葡萄糖和血清胆碱酯酶水平作为预测有机磷中毒中间综合征的指标的有用性。
回顾性评估了 4 年内我院急诊科收治的 71 例有机磷中毒患者。由于缺乏病历，有 4 例患者被排除在研究之外。使用卡方检验分析分类变量，使用 Mann-Whitney U 检验分析非参数变量。
35 例（52.2%）患者为男性，32 例（47.8%）为女性。患者的平均年龄为 39.4±15.9 岁，70.1%的患者已婚。口服摄入（68.7%）是最常见的中毒方式，自杀未遂（67.2%）是最常见的原因。最常见的有机磷农药是甲拌磷（20.8%）、敌敌畏（19.4%）、对硫磷（7.5%）和甲基对硫磷（7.5%）。57 例（85%）患者在急诊观察室接受治疗，10 例（15%）患者收入重症监护病房。11 例（16%）患者发生中间综合征，血清胆碱酯酶水平显著降低（P<0.01），血糖水平显著升高（P=0.037）。
急诊科测定的初始血清胆碱酯酶和血糖水平可能是预测有机磷中毒中间综合征的有用标志物。
