Center for Advanced Bioinformatics and Systems Medicine and Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
Center for Advanced Bioinformatics and Systems Medicine and Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, Republic of Korea Center for Advanced Bioinformatics and Systems Medicine and Department of Biological Sciences, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
Bioinformatics. 2015 May 1;31(9):1508-14. doi: 10.1093/bioinformatics/btu835. Epub 2014 Dec 22.
The mutational status of specific cancer lineages can affect the sensitivity to or resistance against cancer drugs. The MACE database provides web-based interactive tools for interpreting large chemical screening and gene expression datasets of cancer cell lines in terms of mutation and lineage categories. GI50 data of chemicals against individual NCI60 cell lines were normalized and organized to statistically identify mutation- or lineage-specific chemical responses. Similarly, DNA microarray data on NCI60 cell lines were processed to analyze mutation- or lineage-specific gene expression signatures. A combined analysis of GI50 and gene expression data to find potential associations between chemicals and genes is also a capability of this system. This database will provide extensive, systematic information to identify lineage- or mutation-specific anticancer agents and related gene targets.
The MACE web database is available at http://mace.sookmyung.ac.kr/.
Supplementary data are available at Bioinformatics online.
特定癌症谱系的突变状态会影响癌症药物的敏感性或耐药性。MACE 数据库提供了基于网络的交互式工具，可根据突变和谱系类别来解释癌症细胞系的大规模化学筛选和基因表达数据集。针对个别 NCI60 细胞系的化学物质的 GI50 数据经过归一化和组织，以统计方式确定突变或谱系特异性的化学反应。同样，对 NCI60 细胞系的 DNA 微阵列数据进行处理，以分析突变或谱系特异性的基因表达特征。该系统还具有综合分析 GI50 和基因表达数据以发现化学物质和基因之间潜在关联的能力。该数据库将提供广泛的、系统的信息，以识别谱系或突变特异性的抗癌药物和相关的基因靶标。
MACE 网络数据库可在 http://mace.sookmyung.ac.kr/ 上获得。
补充数据可在生物信息学在线获得。
