前驱性阿尔茨海默病表现为与脑淀粉样血管病相关的炎症，伴有自发性淀粉样蛋白相关影像学异常和高脑脊液抗Aβ自身抗体。

Prodromal Alzheimer's disease presenting as cerebral amyloid angiopathy-related inflammation with spontaneous amyloid-related imaging abnormalities and high cerebrospinal fluid anti-Aβ autoantibodies.

作者信息

Boncoraglio Giorgio B, Piazza Fabrizio, Savoiardo Mario, Farina Laura, DiFrancesco Jacopo C, Prioni Sara, Tagliavini Fabrizio, Parati Eugenio A, Giaccone Giorgio

机构信息

Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza, Italy The inflammatory Cerebral Amyloid Angiopathy and Alzheimer's disease Biomarkers International Network (iCAB) Coordinator.

出版信息

J Alzheimers Dis. 2015;45(2):363-7. doi: 10.3233/JAD-142376.

DOI:10.3233/JAD-142376

PMID:25537009

Abstract

Cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare form of vasculitis associated with amyloid-β (Aβ) deposition in vessel walls, has been proposed as a spontaneous human model of the amyloid-related imaging abnormalities (ARIA) occurring after anti-Aβ immunotherapy for the treatment of Alzheimer's disease (AD). We describe a case of a patient with biopsy-proven CAA-ri and prodromal AD, confirmed by means of neuropsychological examination after 20 months follow-up, presenting with ARIA and high levels of cerebrospinal fluid anti-Aβ autoantibodies. This case further supports the analogies between the inflammatory response driven by anti-Aβ immunotherapy and that spontaneously occurring in CAA-ri.

摘要

脑淀粉样血管病相关炎症（CAA-ri）是一种罕见的血管炎形式，与血管壁中淀粉样β蛋白（Aβ）沉积有关，已被认为是阿尔茨海默病（AD）抗Aβ免疫治疗后出现的淀粉样蛋白相关影像异常（ARIA）的自发人体模型。我们描述了一例经活检证实为CAA-ri且患有前驱AD的患者，在20个月的随访后通过神经心理学检查得以确诊，该患者出现了ARIA以及高水平的脑脊液抗Aβ自身抗体。此病例进一步支持了抗Aβ免疫治疗引发的炎症反应与CAA-ri中自发出现的炎症反应之间的相似性。