Wang Xiaoyu, Tai Zongguang, Zhang Wei, Gao Shen
Department of Pharmaceutics, Changhai Hospital, 168# Changhai Road, Shanghai 200433, China.
Curr Gene Ther. 2015;15(2):120-41. doi: 10.2174/1566523214666141224095411.
Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality rates, especially in East Asia. Gene therapy is a potential approach for treating HCC. An efficient and safe gene delivery method is a crucial factor for HCC gene therapy. In recent years, gene delivery systems, including viral and non-viral gene vectors, bacteria, and physical methods, have undergone substantial development. Among them, various non-viral vectors have been studied widely and in detail because they are relatively safe and have a high capacity. In this review, we focus on current and emerging HCC delivery techniques and address the challenges involved in the use and improvement of non-viral vectors.
肝细胞癌（HCC）是一种发病率和死亡率都很高的恶性肿瘤，在东亚地区尤为如此。基因治疗是治疗HCC的一种潜在方法。一种高效且安全的基因递送方法是HCC基因治疗的关键因素。近年来，包括病毒和非病毒基因载体、细菌以及物理方法在内的基因递送系统取得了长足的发展。其中，各种非病毒载体因其相对安全且容量大而得到了广泛而深入的研究。在本综述中，我们重点关注当前和新兴的HCC递送技术，并探讨非病毒载体在使用和改进过程中所面临的挑战。
