免疫抑制宿主皮肤活检标本中存在临床隐匿性巨细胞病毒。

Clinically occult cytomegalovirus present in skin biopsy specimens in immunosuppressed hosts.

作者信息

Horn T D, Hood A F

机构信息

Department of Dermatology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205.

出版信息

J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):781-4. doi: 10.1016/s0190-9622(89)70254-1.

DOI:10.1016/s0190-9622(89)70254-1

PMID:2553786

Abstract

Three patients with acquired immunosuppression in whom skin biopsy specimens were obtained to aid in the diagnosis of varying cutaneous eruptions are described. Amphophilic, granular, intranuclear inclusions within endothelial cells compatible with the presence of cytomegalovirus were found unexpectedly. Clinically, occult cytomegalovirus in the skin may be more common than generally appreciated and may not be the sole cause of the eruption for which biopsy specimens are obtained. Also, the need to remain alert for polymicrobial cutaneous infections in the immunocompromised host is emphasized.

摘要

描述了3例获得性免疫抑制患者，获取其皮肤活检标本以辅助诊断各种皮肤疹。意外发现内皮细胞内存在与巨细胞病毒相符的嗜双色性、颗粒状核内包涵体。临床上，皮肤中隐匿性巨细胞病毒可能比普遍认为的更常见，且可能不是获取活检标本所针对皮疹的唯一病因。此外，强调了对免疫功能低下宿主中多微生物皮肤感染保持警惕的必要性。