Department of Pharmacology, College of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China ; Department of Pharmacology, School of Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
Department of Pharmacology, School of Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
Neural Regen Res. 2012 Oct 25;7(30):2325-32. doi: 10.3969/j.issn.1673-5374.2012.30.001.
Osthole, an effective monomer in Chinese medicinal herbs, can cross the blood-brain barrier and protect against brain injury, with few toxic effects. In this study, a rat model of Alzheimer's disease was established after intracerebroventricular injection of β-amyloid peptide (25-35). Subsequently, the rats were intraperitoneally treated with osthole (12.5 or 25.0 mg/kg) for 14 successive days. Results showed that osthole treatment significantly improved cognitive impairment and protected hippocampal neurons of Alzheimer's disease rats. Also, osthole treatment alleviated suppressed long-term potentiation in the hippocampus of Alzheimer's disease rats. In these osthole-treated Alzheimer's disease rats, the level of glutamate decreased, but there was no significant change in γ-amino-butyric acid. These experimental findings suggest that osthole can improve learning and memory impairment, and increase synaptic plasticity in Alzheimer's disease rats. These effects of osthole may be because of its regulation of central glutamate and γ-amino-butyric acid levels.
蛇床子素是一种中药中的有效单体，能够透过血脑屏障，对脑损伤具有保护作用，且毒性作用较小。本研究通过侧脑室注射β-淀粉样肽（25-35）构建了阿尔茨海默病大鼠模型。随后，大鼠连续 14 天腹腔内给予蛇床子素（12.5 或 25.0mg/kg）进行治疗。结果表明，蛇床子素治疗可显著改善阿尔茨海默病大鼠的认知障碍，并保护其海马神经元。此外，蛇床子素治疗可减轻阿尔茨海默病大鼠海马中受到抑制的长时程增强。在这些经蛇床子素治疗的阿尔茨海默病大鼠中，谷氨酸水平降低，但γ-氨基丁酸没有明显变化。这些实验结果表明，蛇床子素可以改善阿尔茨海默病大鼠的学习记忆障碍，增加其突触可塑性。蛇床子素的这些作用可能与其对中枢谷氨酸和γ-氨基丁酸水平的调节有关。
