Kallmeyer Karlien, Pepper Michael S
University of Pretoria, Department of Immunology , PO Box 2034, Pretoria 0001 , South Africa.
Expert Opin Biol Ther. 2015 Apr;15(4):477-9. doi: 10.1517/14712598.2015.997204. Epub 2014 Dec 24.
A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little is known however about the homing mechanisms of these cells to sites of injury and inflammation. This is important if one is to enhance this process to improve the therapeutic outcome. We have addressed this issue by highlighting what is known and through an analogy with leukocyte homing, and have identified possible areas of future research.
大量临床试验正在进行，以评估间充质基质细胞的治疗潜力。这是基于临床前观察结果，这些结果表明这些细胞可能具有疗效。然而，对于这些细胞归巢至损伤和炎症部位的机制，我们了解得非常少。如果想要增强这一过程以改善治疗效果，这一点很重要。我们通过强调已知内容并与白细胞归巢进行类比来解决这个问题，并确定了未来可能的研究领域。
