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Reduced Gene Expression Levels throughout the Mouse Subthalamic Nucleus Cause Cell Loss and Structural Disorganization Followed by Increased Motor Activity and Decreased Sugar Consumption.整个小鼠丘脑底核基因表达水平降低会导致细胞丢失和结构紊乱，随后运动活动增加和糖消耗减少。
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本文引用的文献

1
Motor vs. cognitive elements of apparent "hyperlocomotion": a conceptual and experimental clarification.明显“活动过度”的运动与认知因素：概念与实验阐释
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E3-4. doi: 10.1073/pnas.1413820112. Epub 2014 Dec 24.
2
Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion.限制丘脑底核中表达Vglut2的亚群中的谷氨酸传递足以导致运动亢进。
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7837-42. doi: 10.1073/pnas.1323499111. Epub 2014 May 12.
3
D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice.D1 多巴胺受体与 PLCβ 的偶联调节小鼠的向前运动。
J Neurosci. 2013 Nov 13;33(46):18125-33. doi: 10.1523/JNEUROSCI.2382-13.2013.
4
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.A53T 小鼠的行为特征揭示了与帕金森病相关的早期和晚期缺陷。
PLoS One. 2013 Aug 1;8(8):e70274. doi: 10.1371/journal.pone.0070274. Print 2013.
5
Role of Basal Ganglia in sleep-wake regulation: neural circuitry and clinical significance.基底神经节在睡眠-觉醒调节中的作用：神经回路和临床意义。
Front Neuroanat. 2010 Nov 23;4:145. doi: 10.3389/fnana.2010.00145. eCollection 2010.
6
Basal ganglia control of sleep-wake behavior and cortical activation.基底神经节对睡眠-觉醒行为和皮层激活的控制。
Eur J Neurosci. 2010 Feb;31(3):499-507. doi: 10.1111/j.1460-9568.2009.07062.x. Epub 2010 Jan 25.

Reply to Konsolaki and Skaliora: Habituation, hyperlocomotion, and "genuine hyperlocomotion".

作者信息

Pupe Stéfano, Schweizer Nadine, Wallén-Mackenzie Åsa

机构信息

Department of Neuroscience, Unit of Functional Neurobiology, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden.

Department of Neuroscience, Unit of Functional Neurobiology, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden

出版信息

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E5. doi: 10.1073/pnas.1417574112. Epub 2014 Dec 24.

DOI:10.1073/pnas.1417574112
PMID:25540419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4291666/
Abstract
摘要