Loesberg C, v d Stelt M, Hooyman G J, Hensen E J, Nijkamp F P
Dept. of Veterinary Pharmacology, University of Utrecht, The Netherlands.
Life Sci. 1989;45(14):1227-35. doi: 10.1016/0024-3205(89)90124-0.
The beta-adrenergic receptor responsiveness of isolated guinea pig tracheal spirals can be negatively affected by intraperitoneal administration of the Gram-negative bacterium Haemophilus influenzae, four days prior to the experiment. The reduction in tracheal relaxation is accompanied by a decrease in beta-adrenergic receptor binding sites in splenic lymphocyte membranes and by a decrease in the fluidity of these membranes. The H. influenzae-induced dysfunction of both the respiratory airway and lymphocyte beta-adrenergic systems can be mimicked by modulating the amount of linoleic acid in the diet. This linoleic acid induced dysfunction of the beta-adrenergic system is also accompanied by a decrease in the plasma membrane fluidity of the splenic lymphocyte membranes of the guinea pigs. The role for plasma membrane fluidity in asthma is discussed in relation to current concepts for atopy.
在实验前四天，腹腔注射革兰氏阴性菌流感嗜血杆菌会对分离的豚鼠气管螺旋条的β-肾上腺素能受体反应性产生负面影响。气管舒张功能的降低伴随着脾淋巴细胞膜中β-肾上腺素能受体结合位点的减少以及这些膜流动性的降低。通过调节饮食中亚油酸的含量，可以模拟流感嗜血杆菌诱导的呼吸道和淋巴细胞β-肾上腺素能系统功能障碍。这种亚油酸诱导的β-肾上腺素能系统功能障碍还伴随着豚鼠脾淋巴细胞膜质膜流动性的降低。结合当前关于特应性的概念，讨论了质膜流动性在哮喘中的作用。
