Madrid Lola, Lanaspa Miguel, Maculuve Sónia Amós, Bassat Quique
Centro de Investigação em Saúde de Manhiça (CISM), Rua 12, Cambeve, Vila de Manhiça, CP1929, Maputo, Mozambique.
Expert Rev Anti Infect Ther. 2015 Feb;13(2):267-77. doi: 10.1586/14787210.2015.995632. Epub 2014 Dec 26.
In the developing world, hypoglycemia is a frequent complication among admitted children, particularly in malaria-endemic areas, and a defining feature of severe malaria and associated with high case fatality rates (CFR). This complication could be much more common than currently considered, particularly because it frequently occurs without a direct immediate clinical translation. Its etiology has not yet been fully understood and is likely to be multifactorial. Routine screening and treatment of hypoglycemia, as recommended by international guidelines, may be challenging to perform in developing countries on account of the limited resources available. In this review, we discuss the published literature in relation with the incidence, risk factors, and consequences of hypoglycemia among malaria patients, aiming to improve our current understanding of this common and life-threatening complication of malaria.
在发展中世界，低血糖是住院儿童中常见的并发症，尤其是在疟疾流行地区，是重症疟疾的一个显著特征，且与高病死率相关。这种并发症可能比目前认为的更为常见，特别是因为它经常在没有直接即时临床表现的情况下发生。其病因尚未完全明确，可能是多因素的。按照国际指南的建议对低血糖进行常规筛查和治疗，在资源有限的发展中国家可能具有挑战性。在本综述中，我们讨论了已发表的有关疟疾患者低血糖的发病率、危险因素及后果的文献，旨在增进我们目前对这种常见且危及生命的疟疾并发症的认识。
