Foo J-P, Aronis K N, Chamberland J P, Mantzoros C S
Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
1] Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA [2] Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA [3] Department of Medicine, Boston Medical Center, Boston University, Boston, MA, USA.
Int J Obes (Lond). 2015 Jun;39(6):945-8. doi: 10.1038/ijo.2014.215. Epub 2014 Dec 26.
Fibroblast growth factor (FGF) 21 is an endocrine factor with an emerging role as a metabolic regulator. We previously reported the presence of a significant day/night variation of FGF-21 in energy-replete, healthy female subjects. However the day/night patterns of secretion in male subjects remain to be fully elucidated. To elucidate day/night pattern of FGF-21 levels in male subjects in the energy-replete state, its relationship to FFA and to investigate whether a sexual dimorphism exists in FGF-21 physiology.
Eight healthy lean male subjects were studied for up to 5 days while on an isocaloric diet. Blood samples were obtained for measurement of FGF-21 and free fatty acids (FFA) hourly from 0800 AM on day 4 till 0800AM on day 5.
FGF-21 did not exhibit any statistically significant day/night variation pattern of circulating FGF-21 levels during the isocaloric fed state in male subjects. FGF-21 levels in male subjects are closely cross-correlated with FFA levels, similar to female subjects.
A sexual dimorphism exists in FGF-21 physiology; that as opposed to female subjects, no significant day/night variation exists in FGF-21 rhythm in male subjects in the energy-replete state. Circulating pattern of FGF-21, similar to the female subjects, was highly cross-correlated to the FFA levels in the male subjects, signifying that the sexual dimorphism in FGF-21 physiology may be related to the differing lipid metabolism in both the genders.
成纤维细胞生长因子（FGF）21是一种内分泌因子，在代谢调节中发挥着越来越重要的作用。我们之前报道，在能量充足的健康女性受试者中，FGF-21存在显著的昼夜变化。然而，男性受试者中FGF-21的昼夜分泌模式仍有待充分阐明。为了阐明能量充足状态下男性受试者FGF-21水平的昼夜模式、其与游离脂肪酸（FFA）的关系，并研究FGF-21生理学中是否存在性别差异。
八名健康的瘦男性受试者在等热量饮食条件下接受了长达5天的研究。从第4天上午8点到第5天上午8点，每小时采集血样，用于检测FGF-21和游离脂肪酸（FFA）。
在男性受试者等热量进食状态下，循环FGF-21水平未表现出任何具有统计学意义的昼夜变化模式。男性受试者的FGF-21水平与FFA水平密切相关，这与女性受试者相似。
FGF-21生理学中存在性别差异；与女性受试者不同，能量充足状态下男性受试者的FGF-21节律不存在显著的昼夜变化。与女性受试者相似，男性受试者中FGF-21的循环模式与FFA水平高度相关，这表明FGF-21生理学中的性别差异可能与两性不同的脂质代谢有关。
