通过生物电阻抗分析评估普拉德-威利综合征肥胖女性的去脂体重。
Assessment of fat-free mass from bioelectrical impedance analysis in obese women with Prader-Willi syndrome.
作者信息
Bedogni Giorgio, Grugni Graziano, Tringali Gabriella, Agosti Fiorenza, Sartorio Alessandro
机构信息
a Liver Research Center , Basovizza , Trieste , Italy .
b International Center for the Assessment of Nutritional Status (ICANS), University of Milano , Milano , Italy .
出版信息
Ann Hum Biol. 2015;42(6):538-42. doi: 10.3109/03014460.2014.990922. Epub 2014 Dec 26.
BACKGROUND
Fat-free mass (FFM) is lower in obese subjects with Prader-Willi syndrome (PWS) than in obese subjects without PWS. FFM prediction equations developed in non-PWS subjects may, thus, not work in PWS subjects.
AIM
To test whether the estimation of FFM from bioelectrical impedance analysis (BIA) in PWS subjects requires population-specific equations.
METHODS
Using dual-energy X-ray absorptiometry, this study measured FFM in 27 PWS and 56 non-PWS obese women and evaluated its association with the impedance index at 50 kHz (ZI50), i.e. the ratio between squared height and whole-body impedance at 50 kHz.
RESULTS
At the same level of ZI50, PWS women had a lower FFM than non-PWS women. However, when PWS-specific equations were used, FFM was accurately estimated at the population level. An equation employing a dummy variable coding for PWS status was able to explain 85% of the variance of FFM with a root mean squared error of 3.3 kg in the pooled sample (n = 83).
CONCLUSION
Population-specific equations are needed to estimate FFM from BIA in obese PWS women.
背景
患有普拉德-威利综合征（PWS）的肥胖受试者的去脂体重（FFM）低于无PWS的肥胖受试者。因此，在非PWS受试者中开发的FFM预测方程可能不适用于PWS受试者。
目的
测试在PWS受试者中通过生物电阻抗分析（BIA）估算FFM是否需要特定人群的方程。
方法
本研究使用双能X线吸收法测量了27名PWS肥胖女性和56名非PWS肥胖女性的FFM，并评估了其与50kHz时的阻抗指数（ZI50）的相关性，即身高平方与50kHz时全身阻抗的比值。
结果
在相同的ZI50水平下，PWS女性的FFM低于非PWS女性。然而，当使用特定于PWS的方程时，在人群水平上能够准确估算FFM。在合并样本（n = 83）中，采用PWS状态虚拟变量编码的方程能够解释FFM方差的85%，均方根误差为3.3kg。
结论
在肥胖的PWS女性中，需要特定人群的方程通过BIA来估算FFM。
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