Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
Centro Italiano per la cura e il Benessere del paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, Endocrinology Unit, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
Nutrients. 2020 Jul 11;12(7):2065. doi: 10.3390/nu12072065.
Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subjects and in subjects with obesity and is obtained from bioelectrical impedance analysis (BIA). The aim of this study was to validate the PhA in PWS adults as a potential biomarker of LGI. In this single-center, cross-sectional study, fifteen PWS adults (six males, aged 19-41 years, and body mass index (BMI) 31.0-68.0 Kg/m) and fifteen control subjects matched by gender, age, and BMI were evaluated. PhA values were significantly lower ( < 0.001), while high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher ( < 0.001) in PWS adults compared with controls ( < 0.001), without a gender difference in the latter. After adjustment for gender, BMI, and waist circumference, significant correlation was found between PhA and hs-CRP levels (r = -0.69, = 0.01). At the ROC analysis, the threshold value of PhA predicting the highest hs-CRP levels above the median value was found at PhA ≤ 4.8° ( = 0.01; AUC, 0.82; standard error, 0.12; 95% CI, 0.58 to 1.00). These results suggest that PWS adults had a significant higher degree of LGI compared with their counterparts. Moreover, our finding suggest that PhA is a valid biomarker of LGI also in PWS adults.
普拉德-威利综合征（PWS）是最常见的遗传性肥胖综合征。肥胖相关并发症，主要与慢性低度全身炎症（LGI）有关，是 PWS 成人患者死亡和发病的最常见原因。相位角（PhA）是一种易于筛选健康受试者和肥胖受试者 LGI 状态的工具，通过生物电阻抗分析（BIA）获得。本研究旨在验证 PhA 在 PWS 成人中的潜在 LGI 生物标志物作用。在这项单中心、横断面研究中，共评估了 15 名 PWS 成年患者（6 名男性，年龄 19-41 岁，体重指数（BMI）31.0-68.0 Kg/m）和 15 名按性别、年龄和 BMI 匹配的对照者。与对照组相比，PWS 成年患者的 PhA 值明显降低（ < 0.001），而高敏 C 反应蛋白（hs-CRP）水平明显升高（ < 0.001）（ < 0.001），后者在性别间无差异。在调整性别、BMI 和腰围后，PhA 与 hs-CRP 水平之间存在显著相关性（r = -0.69， = 0.01）。在 ROC 分析中，发现预测 hs-CRP 水平高于中位数的 PhA 截断值为 PhA ≤ 4.8°（ = 0.01；AUC，0.82；标准误，0.12；95%CI，0.58 至 1.00）。这些结果表明，与对照组相比，PWS 成年患者存在明显更高程度的 LGI。此外，我们的研究结果还表明，PhA 也是 PWS 成年患者 LGI 的有效生物标志物。
