Zacny J P, Chait L D
Department of Psychiatry, Pritzker School of Medicine, The University of Chicago 60637.
Pharmacol Biochem Behav. 1989 Jun;33(2):481-4. doi: 10.1016/0091-3057(89)90534-0.
Marijuana smokers are frequently observed to hold the smoke in their lungs for prolonged periods (10-15 sec) apparently in the belief that prolonged breathholding intensifies the effects of the drug. The actual influence of breathhold duration on response to marijuana smoke has not been studied. The present study examined the effects of systematic manipulation of breathhold duration on the physiological, cognitive and subjective response to marijuana smoke in a group of eight regular marijuana smokers. Subjects were exposed to each of three breathhold duration conditions (0, 10 and 20 sec) on three occasions, scheduled according to a randomized block design. A controlled smoking procedure was used in which the number of puffs, puff volume and postpuff inhalation volume were held constant. Expired air carbon monoxide levels were measured before and after smoking to monitor smoke intake. Typical marijuana effects (increased heart rate, increased ratings of "high" and impaired memory performance) were observed under each of the breathhold conditions, but there was little evidence that response to marijuana was a function of breathhold duration.
经常观察到吸食大麻者会将烟雾长时间（10 - 15秒）留在肺中，显然他们认为长时间屏气会增强药物的效果。屏气时间对大麻烟雾反应的实际影响尚未得到研究。本研究在一组八名经常吸食大麻者中，考察了系统操纵屏气时间对大麻烟雾的生理、认知和主观反应的影响。受试者按照随机区组设计，分三次暴露于三种屏气时间条件（0、10和20秒）下。采用了一种控制吸烟程序，其中抽吸次数、抽吸量和抽吸后吸入量保持恒定。在吸烟前后测量呼出气体中的一氧化碳水平，以监测烟雾摄入量。在每种屏气条件下都观察到了典型的大麻效应（心率加快、“兴奋”评分增加和记忆表现受损），但几乎没有证据表明对大麻的反应是屏气时间的函数。
