Balos Tuncer Burcu, Canigur Bavbek Nehir, Ozkan Cigdem, Tuncer Cumhur, Eroglu Altinova Alev, Gungor Kahraman, Akturk Mujde, Balos Toruner Fusun
Department of Orthodontics, Faculty of Dentistry.
Acta Odontol Scand. 2015 Aug;73(6):433-40. doi: 10.3109/00016357.2014.979868. Epub 2014 Dec 29.
The aim of this study was to assess differences in craniofacial characteristics, upper spine and pharyngeal airway morphology in patients with acromegaly compared with healthy individuals.
Twenty-one patients with acromegaly were compared with 22 controls by linear and angular measurements on cephalograms. The differences between the mean values of cephalometric parameters were analyzed with Mann-Whitney U-test.
With respect to controls, anterior (p<0.05), middle (p<0.01) and posterior (p<0.05) cranial base lengths were increased, sella turcica was enlarged (p<0.001) and upper spine morphology demonstrated differences in the height of atlas (p<0.01) and axis (p<0.05) in patients with acromegaly. Craniofacial changes were predominantly found in the frontal bone (p<0.01) and the mandible (p<0.05). As for the airway, patients with acromegaly exhibited diminished dimensions at nasal (p<0.001), uvular (p<0.01), mandibular (p<0.01) pharyngeal levels and at the narrowest point of the pharyngeal airway space (p<0.001) compared to healthy controls. Soft palate width was significantly higher (p<0.001) and the hyoid bone was more vertically positioned (p<0.01) in patients with acromegaly.
Current results point to the importance of the reduced airway dimensions and that dentists and/or orthodontists should be aware of the cranial or dental abnormalities in patients with acromegaly.
本研究旨在评估肢端肥大症患者与健康个体相比在颅面特征、上脊柱和咽气道形态方面的差异。
通过对头影测量片进行线性和角度测量，将21例肢端肥大症患者与22例对照者进行比较。采用曼-惠特尼U检验分析头影测量参数均值之间的差异。
与对照组相比，肢端肥大症患者的前颅底长度（p<0.05）、中颅底长度（p<0.01）和后颅底长度（p<0.05）增加，蝶鞍增大（p<0.001），上脊柱形态显示寰椎高度（p<0.01）和枢椎高度（p<0.05）存在差异。颅面变化主要见于额骨（p<0.01）和下颌骨（p<0.05）。至于气道，与健康对照组相比，肢端肥大症患者在鼻腔（p<0.001）、悬雍垂（p<0.01）、下颌（p<0.01）咽水平以及咽气道间隙最窄点（p<0.001）的尺寸减小。肢端肥大症患者的软腭宽度显著更高（p<0.001），舌骨位置更垂直（p<0.01）。
目前的结果表明气道尺寸减小的重要性，牙医和/或正畸医生应意识到肢端肥大症患者的颅骨或牙齿异常。
