Cotano Urrutikoetxea J R, Madariaga Vidal M A, Pérez San José C, Sabas Olabarría J A, Barrallo Villar G, Duque de las Heras C
Rev Esp Enferm Apar Dig. 1989 Sep;76(3):285-9.
Insulinomas are rare tumors whose difficult diagnosis is usually delayed with respect to appearance of the first symptoms. The Whipple triad (symptoms of hypoglycemia, low blood glucose and rapid alleviation of symptoms after glucose administration) associated with an increase in plasma immunoreactive insulin (IRI) and low blood glucose levels constitute the diagnostic basis of insulinoma as the cause of organic hypoglycemia. Curative treatment entails surgery and its success will depend on the location of the tumor. Selective arteriography and, more recently, percutaneous transhepatic insulin determination (IRI) in the splenoportal axis have a diagnostic rate of 90%. Nevertheless, none of these topographic diagnostic methods replaces meticulous intraoperative exploration of the pancreas, which in our case was definitive for cure.
胰岛素瘤是罕见肿瘤,其诊断困难,通常在出现首发症状后延迟诊断。与血浆免疫反应性胰岛素(IRI)升高和低血糖水平相关的Whipple三联征(低血糖症状、低血糖以及葡萄糖给药后症状迅速缓解)构成了胰岛素瘤作为器质性低血糖病因的诊断基础。根治性治疗需要手术,其成功与否取决于肿瘤的位置。选择性动脉造影以及最近在脾门静脉轴进行的经皮经肝胰岛素测定(IRI)的诊断率为90%。然而,这些定位诊断方法都不能替代对胰腺进行细致的术中探查,在我们的病例中,这对治愈起到了决定性作用。