Fuwa Haruhiko, Sakamoto Keita, Muto Takashi, Sasaki Makoto
Graduate School of Life Sciences, Tohoku University , 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Org Lett. 2015 Jan 16;17(2):366-9. doi: 10.1021/ol503491t. Epub 2014 Dec 26.
A concise synthetic entry to the C15-C38 fragment of okadaic acid by exploiting a Suzuki-Miyaura reaction for the rapid assembly of the spiroacetal substructures has been developed. The present synthesis was completed in 19 linear steps from a commercially available material, showcasing the efficiency of our synthetic strategy.
通过利用铃木-宫浦反应快速组装螺缩醛亚结构，已开发出一种简洁的合成方法来合成冈田酸的C15 - C38片段。目前的合成从市售原料开始，经过19步线性反应完成，展示了我们合成策略的效率。
