Rutten Geert-Jan
Department of Neurosurgery, St Elisabeth Hospital, The Netherlands.
Brain Lang. 2015 Feb;141:77-9. doi: 10.1016/j.bandl.2014.11.014. Epub 2014 Dec 30.
Cortical and axonal electrical stimulation of left premotor cortex and SMA during awake brain surgery yielded unique behavioral responses. In two patients, there was involuntary acceleration of speech (i.e., speech hastening) during a counting or picture naming task. In one patient, stimulation led to a deceleration of the rate with which three different tasks were performed (arm movements, finger tapping and counting). Possible explanatory mechanisms are discussed, and the literature on so-called "negative motor areas" is shortly reviewed. It is argued that the function of loops between cortex and basal ganglia were modulated via stimulation of frontostriatal and/or fronto-opercular pathways.
在清醒开颅手术期间，对左侧运动前区皮层和辅助运动区进行皮层及轴突电刺激产生了独特的行为反应。在两名患者中，在计数或图片命名任务期间出现了言语不自主加速（即语速加快）。在一名患者中，刺激导致执行三项不同任务（手臂运动、手指轻敲和计数）的速度减慢。文中讨论了可能的解释机制，并简要回顾了关于所谓“负运动区”的文献。有人认为，通过刺激额纹状体和/或额眶通路可调节皮层与基底神经节之间环路的功能。
