在过去十年中，乙型肝炎病毒是如何影响宿主基因组的？
How did hepatitis B virus effect the host genome in the last decade?
作者信息
Ozkal-Baydin Pinar
机构信息
Pinar Ozkal-Baydin, Ankara University, Stem Cell Institute, 06520 Ankara, Turkey.
出版信息
World J Hepatol. 2014 Dec 27;6(12):851-9. doi: 10.4254/wjh.v6.i12.851.
Abstract
The principal reason of chronic liver disease, cirrhosis and hepatocellular carcinoma is chronic viral hepatitis all over the world. Hepatitis B virus (HBV) has some mutagenic effects on the host genome. HBV may be exhibiting these mutagenic effects through integrating into the host genome, through its viral proteins or through some epigenetic mechanisms related with HBV proteins. This review aims to summarize the molecular mechanisms used by HBV for effecting host genome determined in the last decade. The focus will be on the effects of integration, HBV proteins, especially HBV X protein and epigenetic mechanisms on the host genome. These interactions between HBV and the host genome also forms the underlying mechanisms of the evolution of hepatocellular carcinoma.
摘要
在全球范围内，慢性肝病、肝硬化和肝细胞癌的主要原因是慢性病毒性肝炎。乙型肝炎病毒（HBV）对宿主基因组具有一些诱变作用。HBV可能通过整合到宿主基因组中、通过其病毒蛋白或通过一些与HBV蛋白相关的表观遗传机制来展现这些诱变作用。本综述旨在总结过去十年中确定的HBV影响宿主基因组所使用的分子机制。重点将放在整合、HBV蛋白，尤其是HBV X蛋白以及表观遗传机制对宿主基因组的影响上。HBV与宿主基因组之间的这些相互作用也构成了肝细胞癌演变的潜在机制。
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