Cerny T, Meier C
Institut für Medizinische Onkologie, Universität Bern, Inselspital.
Schweiz Med Wochenschr. 1989 Aug 26;119(34):1137-47.
Neurotoxicity is of increasing importance in the treatment of cancer patients. Since the dose-limiting hematological toxicity of most cytostatic drugs can now be overcome by modern supportive therapy, high-dose chemotherapy with curative intent can be used more often. Non-hematological toxicities such as neurotoxicity will therefore become dose-limiting with greater frequency, and to avoid disabling neurological side effects of chemotherapy the drug-induced neurological disturbances must be recognized before irreversible damage has occurred. The neurological side effects of the cytostatic drugs are reviewed.
神经毒性在癌症患者治疗中的重要性日益增加。由于现代支持性疗法现已能够克服大多数细胞毒性药物的剂量限制性血液学毒性，因此可以更频繁地使用具有治愈意图的高剂量化疗。诸如神经毒性之类的非血液学毒性将因此更频繁地成为剂量限制性因素，并且为避免化疗导致的致残性神经副作用，必须在发生不可逆损伤之前识别出药物引起的神经紊乱。本文对细胞毒性药物的神经副作用进行了综述。
