Tomkowiak Michael T, Raval Amish N, Van Lysel Michael S, Funk Tobias, Speidel Michael A
University of Wisconsin-Madison, Department of Medical Physics, 1111 Highland Ave, Madison, Wisconsin 53705, United States.
University of Wisconsin-Madison, Department of Medicine, 600 Highland Ave, Madison, Wisconsin 53792, United States.
J Med Imaging (Bellingham). 2014 Oct;1(3). doi: 10.1117/1.JMI.1.3.033504.
Proper sizing of interventional devices to match coronary vessel dimensions improves procedural efficiency and therapeutic outcomes. We have developed a method that uses an inverse geometry x-ray fluoroscopy system [scanning beam digital x-ray (SBDX)] to automatically determine vessel dimensions from angiograms without the need for magnification calibration or optimal views. For each frame period (1/15th of a second), SBDX acquires a sequence of narrow beam projections and performs digital tomosynthesis at multiple plane positions. A three-dimensional model of the vessel is reconstructed by localizing the depth of the vessel edges from the tomosynthesis images, and the model is used to calculate the length and diameter in units of millimeters. The algorithm performance was evaluated in a healthy porcine model by comparing end-diastolic length and diameter measurements from SBDX to coronary computed tomography angiography (CCTA) and intravascular ultrasound (IVUS), respectively. The length error was -0.49 ± 1.76 mm(SBDX- CCTA, mean ± 1 SD). The diameter error was 0.07 ± 0.27 mm (SBDX - minimum IVUS diameter, mean ± 1 SD). The agreement between SBDX-based vessel sizing and gold standard techniques supports the feasibility of calibration-free coronary vessel sizing using inverse geometry x-ray fluoroscopy.
使介入设备的尺寸与冠状动脉血管尺寸相匹配可提高手术效率和治疗效果。我们开发了一种方法，该方法使用反几何X射线荧光透视系统[扫描束数字X射线（SBDX）]从血管造影照片中自动确定血管尺寸，而无需进行放大校准或获取最佳视图。对于每个帧周期（1/15秒），SBDX获取一系列窄束投影，并在多个平面位置进行数字断层合成。通过从断层合成图像中定位血管边缘的深度来重建血管的三维模型，并使用该模型以毫米为单位计算长度和直径。通过分别比较SBDX与冠状动脉计算机断层扫描血管造影（CCTA）和血管内超声（IVUS）测量的舒张末期长度和直径，在健康猪模型中评估了该算法的性能。长度误差为-0.49±1.76毫米（SBDX - CCTA，平均值±1标准差）。直径误差为0.07±0.27毫米（SBDX - 最小IVUS直径，平均值±1标准差）。基于SBDX的血管尺寸测量与金标准技术之间的一致性支持了使用反几何X射线荧光透视进行无校准冠状动脉血管尺寸测量的可行性。
