Arrigo Mattia, Maisano Francesco, Haueis Sabine, Binder Ronald K, Taramasso Maurizio, Nietlispach Fabian
Department of Cardiology, University Heart Center, Zurich, Switzerland.
Department of Cardiovascular Surgery, University Heart Center, Zurich, Switzerland.
Catheter Cardiovasc Interv. 2015 Jun;85(7):1248-53. doi: 10.1002/ccd.25799. Epub 2015 Jan 30.
Performing transcatheter aortic valve implantation (TAVI) with the use of minimal contrast in patients at high-risk for acute kidney injury (AKI).
Contrast-induced nephropathy (CIN) is a major cause of AKI following TAVI and is associated with increased morbidity and mortality. The amount of contrast media used increases the risk for CIN.
Computed tomography was omitted during the screening process. For the procedure transfemoral access was default. The self-expanding CoreValve prosthesis was chosen in all patients to minimize the risk of annular rupture in case of oversizing. Valve sizing was based on echocardiography, aortography, calcification on fluoroscopy, as well as weight and height of the patient. A single contrast injection was performed to confirm correct position of the pigtail catheter at the level of the annulus. The pigtail then served as the marker for the device landing zone. Intraprocedural assessment of the implantation result relied on echocardiography and hemodynamics.
Five patients with severe aortic stenosis and at high risk for developing CIN were included. Device success was achieved in all patients and no major complications occurred. The median dose of injected contrast media was 8 ml (4-9). All but one patient had improved renal function after the intervention compared to baseline.
Our study shows feasibility of performing TAVI with a single minimal contrast media injection, using a self-expandable valve. This technique has the potential to reduce the incidence of CIN.
在急性肾损伤(AKI)高危患者中使用最少的造影剂进行经导管主动脉瓣植入术(TAVI)。
造影剂肾病(CIN)是TAVI术后AKI的主要原因,与发病率和死亡率增加相关。使用的造影剂剂量会增加CIN的风险。
在筛查过程中省略计算机断层扫描。手术默认采用经股动脉入路。所有患者均选择自膨胀式CoreValve人工瓣膜,以将尺寸过大时发生瓣环破裂的风险降至最低。瓣膜尺寸根据超声心动图、主动脉造影、透视下的钙化情况以及患者的体重和身高来确定。进行单次造影剂注射以确认猪尾导管在瓣环水平的正确位置。然后猪尾导管作为装置着陆区的标记。术中对植入结果的评估依赖于超声心动图和血流动力学。
纳入了5例严重主动脉瓣狭窄且发生CIN高危的患者。所有患者均成功植入装置,未发生重大并发症。注射造影剂的中位剂量为8 ml(4 - 9)。与基线相比,除1例患者外,所有患者术后肾功能均有所改善。
我们的研究表明,使用自膨胀瓣膜单次注射最少造影剂进行TAVI是可行的。该技术有可能降低CIN的发生率。