Nair G B, Pal S C
Trop Gastroenterol. 1989 Jul-Sep;10(3):133-41.
The pathogenic personality or the criteria required to be a successful pathogen, of enteric bacteria includes, among others, the ability to produce potent proteins which by different intracellular mechanisms elicit what we overtly see as diarrhoea. Enteropathogens belonging to several genera like Vibrio, Escherichia, Shigella, Salmonella, Campylobacter, Aeromonas and Yersinia include species capable of elaborating strikingly similar exotoxins which seem to share common mechanisms of action involving specific receptor binding, internalization of the toxin followed by interaction with an intracellular target. It is now clear that there are several families of structurally, functionally and immunologically identical bacterial enterotoxins. In this communication, we have reviewed the recent developments on the various families of structurally homologous and antigenically cross reacting enteric toxins.
肠道细菌的致病特性或成为成功致病菌所需的标准包括，除其他外，产生强效蛋白质的能力，这些蛋白质通过不同的细胞内机制引发我们明显看到的腹泻症状。属于几个属的肠道病原体，如弧菌属、大肠杆菌属、志贺氏菌属、沙门氏菌属、弯曲杆菌属、气单胞菌属和耶尔森氏菌属，包括能够产生惊人相似外毒素的物种，这些外毒素似乎具有涉及特定受体结合、毒素内化随后与细胞内靶点相互作用的共同作用机制。现在很清楚，存在几个结构、功能和免疫相同的细菌肠毒素家族。在本通讯中，我们综述了结构同源和抗原交叉反应的肠道毒素各家族的最新进展。
