Price Jenessa S, Shear Paula, Lisdahl Krista M
McLean Hospital - Harvard Medical School, Belmont, Massachusetts, United States of America.
Department of Psychology, University of Cincinnati, Cincinnati, Ohio, United States of America.
PLoS One. 2014 Dec 29;9(12):e115645. doi: 10.1371/journal.pone.0115645. eCollection 2014.
Studies have demonstrated verbal memory deficits associated with past year ecstasy use, although specific underlying components of these deficits are less understood. Further, prior research suggests potential gender differences in ecstasy-induced serotonergic changes. Therefore, the current study investigated whether gender moderated the relationship between ecstasy exposure and components of verbal memory after controlling for polydrug use and confounding variables.
Data were collected from 65 polydrug users with a wide range of ecstasy exposure (ages 18-35; 48 ecstasy and 17 marijuana users; 0-2310 ecstasy tablets). Participants completed a verbal learning and memory task, psychological questionnaires, and a drug use interview.
Increased past year ecstasy exposure predicted poorer short and long delayed free and cued recalls, retention, and recall discrimination. Male ecstasy users were more susceptible to dose-dependent deficits in retention than female users.
Past year ecstasy consumption was associated with verbal memory retrieval, retention, and discrimination deficits in a dose-dependent manner in a sample of healthy young adult polydrug users. Male ecstasy users were at particular risk for deficits in retention following a long delay. Gender difference may be reflective of different patterns of polydrug use as well as increased hippocampal sensitivity. Future research examining neuronal correlates of verbal memory deficits in ecstasy users are needed.
研究表明，过去一年使用摇头丸与言语记忆缺陷有关，尽管这些缺陷的具体潜在成分尚不太清楚。此外，先前的研究表明，摇头丸引起的血清素变化可能存在性别差异。因此，本研究调查了在控制多药使用和混杂变量后，性别是否调节了摇头丸暴露与言语记忆成分之间的关系。
收集了65名多药使用者的数据，他们有广泛的摇头丸暴露史（年龄18 - 35岁；48名摇头丸使用者和17名大麻使用者；0 - 2310片摇头丸）。参与者完成了一项言语学习和记忆任务、心理问卷以及一次药物使用访谈。
过去一年摇头丸暴露增加预示着短期和长期延迟自由回忆和线索回忆、记忆保持以及回忆辨别能力较差。男性摇头丸使用者比女性使用者更容易受到记忆保持中剂量依赖性缺陷的影响。
在健康年轻成人多药使用者样本中，过去一年使用摇头丸与言语记忆检索、记忆保持和辨别缺陷呈剂量依赖性相关。男性摇头丸使用者在长时间延迟后存在记忆保持缺陷的特别风险。性别差异可能反映了多药使用的不同模式以及海马体敏感性增加。需要进一步研究检查摇头丸使用者言语记忆缺陷的神经元相关性。
