Kalhapure Rahul S, Suleman Nadia, Mocktar Chunderika, Seedat Nasreen, Govender Thirumala
Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa.
J Pharm Sci. 2015 Mar;104(3):872-905. doi: 10.1002/jps.24298. Epub 2014 Dec 24.
Formulation scientists are recognizing nanoengineered drug delivery systems as an effective strategy to overcome limitations associated with antibiotic drug therapy. Antibiotics encapsulated into nanodelivery systems will contribute to improved management of patients with various infectious diseases and to overcoming the serious global burden of antibiotic resistance. An extensive review of several antibiotic-loaded nanocarriers that have been formulated to target drugs to infectious sites, achieve controlled drug release profiles, and address formulation challenges, such as low-drug entrapment efficiencies, poor solubility and stability is presented in this paper. The physicochemical properties and the in vitro/in vivo performances of various antibiotic-loaded delivery systems, such as polymeric nanoparticles, micelles, dendrimers, liposomes, solid lipid nanoparticles, lipid-polymer hybrid nanoparticles, nanohybirds, nanofibers/scaffolds, nanosheets, nanoplexes, and nanotubes/horn/rods and nanoemulsions, are highlighted and evaluated. Future studies that will be essential to optimize formulation and commercialization of these antibiotic-loaded nanosystems are also identified. The review presented emphasizes the significant formulation progress achieved and potential that novel nanoengineered antibiotic drug delivery systems have for enhancing the treatment of patients with a range of infections.
制剂科学家们正认识到纳米工程药物递送系统是克服抗生素药物治疗相关局限性的有效策略。封装在纳米递送系统中的抗生素将有助于改善各种传染病患者的治疗管理，并有助于克服抗生素耐药性这一严重的全球负担。本文对几种载抗生素纳米载体进行了广泛综述，这些纳米载体已被设计用于将药物靶向感染部位、实现药物控释，并应对诸如药物包封效率低、溶解性和稳定性差等制剂挑战。文中重点介绍并评估了各种载抗生素递送系统的物理化学性质以及体外/体内性能，这些系统包括聚合物纳米颗粒、胶束、树枝状大分子、脂质体、固体脂质纳米颗粒、脂质-聚合物杂化纳米颗粒、纳米杂化物, 纳米纤维/支架、纳米片、纳米复合物以及纳米管/角/棒和纳米乳液。文中还确定了对优化这些载抗生素纳米系统的制剂和商业化至关重要的未来研究方向。本文的综述强调了在制剂方面取得的重大进展以及新型纳米工程抗生素药物递送系统在增强一系列感染患者治疗效果方面的潜力。
