Nakajima T, Yutsudo M, Ikekawa S, Hayasaka K, Ishihara K, Gotoh M, Shimosato Y, Tsunokawa Y, Terada M
Pathology Division, National Cancer Center, Research Institute, Tokyo, Japan.
Acta Pathol Jpn. 1989 Aug;39(8):528-32. doi: 10.1111/j.1440-1827.1989.tb01519.x.
Multiple dark brown papillomatous tumors, showing some histological features of verrucous carcinoma or giant condyloma, developed mainly in the anogenital region of a Japanese woman. The tumors first appeared when she was 51 years old and annoyed her for over 20 years with several recurrences without any frank malignant transformation, after surgery. Immunohistochemically, papillomavirus genus-specific antigen was demonstrated only in small foci of the lesions resected at first operation. Southern blot analysis revealed human papillomavirus type 6b-related DNA in a surgically resected specimen. The possible role of the human papillomavirus in the genesis of this unique tumor is discussed.
一名日本女性的肛门生殖器区域主要出现了多个深褐色乳头状瘤，呈现出疣状癌或巨大尖锐湿疣的一些组织学特征。这些肿瘤首次出现于她51岁时，术后复发数次，困扰了她20多年，未发生任何明显的恶性转化。免疫组织化学检测显示，仅在首次手术切除的病变小灶中检测到乳头瘤病毒属特异性抗原。Southern印迹分析在手术切除的标本中发现了人乳头瘤病毒6b型相关DNA。本文讨论了人乳头瘤病毒在这种独特肿瘤发生中的可能作用。
