Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Department of Oncology , Beixiange 5, Xicheng District, Beijing 100053 , China +86 10 88001221 ; +86 10 88001340 ;
Expert Opin Ther Targets. 2015 Feb;19(2):227-43. doi: 10.1517/14728222.2014.980815. Epub 2014 Dec 30.
Numerous studies have shown that an intact CNS is required for the conscious perception of cancer-induced bone pain (CIBP) and that changes in the CNS are clearly evident. Accordingly, the blockage of nociceptive stimulus into the CNS can effectively relieve or markedly attenuate CIBP, revealing the clinical implication of the blockage of ongoing peripheral inputs for the control of CIBP.
In this review, the heterogeneity and excitability of nociceptors in bone are covered. Furthermore, their role in initiating and maintaining CIBP is also described.
Developing mechanistic therapies to treat CIBP is a challenge, but they have the potential to fundamentally change our ability to effectively block/relieve CIBP and increase the functional status and quality of life of patients with bone metastasis. Further studies are desperately needed at both the preclinical and clinical levels to determine whether the targets as mentioned in this review are viable and feasible for patient populations.
大量研究表明，中枢神经系统（CNS）的完整对于癌症骨痛（CIBP）的意识感知是必需的，且中枢神经系统的变化是明显的。因此，阻断传入中枢神经系统的伤害性刺激可以有效地缓解或明显减轻 CIBP，这揭示了阻断持续性外周传入对于控制 CIBP 的临床意义。
本文综述了骨中伤害感受器的异质性和兴奋性，以及它们在引发和维持 CIBP 中的作用。
开发针对 CIBP 的机制疗法是一项挑战，但它们有可能从根本上改变我们有效阻断/缓解 CIBP 的能力，并提高骨转移患者的功能状态和生活质量。在临床前和临床层面都迫切需要进一步研究，以确定本文中提到的这些靶点对于患者群体是否可行。
