Armentano R, Levenson J, Cabrera E, Pichel R, Simon A
Centre de diagnostic, INSERM U 28, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1989 Jul;82(7):1159-62.
Effects of experimental calcinosis induced by daily overdose of 500.000 IU Vit D3 during 10 days were studied in 6 mongrel conscious dogs chronically instrumented with intra-aortic Konigsberg microtransducer and two ultrasonic piezo-electric crystals diametrically opposed in the adventitia of the descending thoracic aorta. Simultaneous recording of instantaneous aortic pressure and diameter waves in basal state and during transient acute hypertension induced by intravenous angiotensin bolus (0.1 microgram/kg) allowed to obtain the pressure (y) diameter (x) relationship of the aorta according to an exponential regression: P = expo (beta D + A), with a highly significant correlation coefficient in all animals (r greater than 0.99). (table; see text) Anatomopathological studies of aortas revealed abnormal calcium deposition, ruptures of elastic fibers and disorganization of collagen. Thus, a striking decrease in aortic rigidity is observed after calcinosis in relation with structural changes of elastic materials and responsible in part for a reduction in pulsatile pressure; moreover this unexpected phenomena might represent an initiative process of development of aortic aneurysms.
对6只长期植入主动脉内柯尼斯堡微型传感器以及在胸降主动脉外膜上呈直径对置的两个超声压电晶体的杂种清醒犬，研究了连续10天每日过量注射500,000国际单位维生素D3所诱导的实验性钙质沉着的影响。在基础状态以及静脉注射血管紧张素推注（0.1微克/千克）诱导的短暂急性高血压期间，同时记录瞬时主动脉压力和直径波，从而根据指数回归获得主动脉的压力（y）-直径（x）关系：P = expo（βD + A），在所有动物中相关系数都非常显著（r＞0.99）。（表格；见正文）主动脉的解剖病理学研究显示有异常钙沉积、弹性纤维断裂和胶原紊乱。因此，钙质沉着后观察到主动脉僵硬度显著降低，这与弹性材料的结构变化有关，部分导致搏动压力降低；此外，这种意外现象可能代表主动脉瘤发展的起始过程。
