Ferguson C M, Powell R W
Department of Surgery, Emory University School of Medicine, Atlanta, GA.
Arch Surg. 1989 Nov;124(11):1338-41. doi: 10.1001/archsurg.1989.01410110100020.
To better define the risk of breast cancer in young patients, a retrospective review of all breast biopsies in women under age 40 years at Grady Memorial Hospital, Atlanta, from Dec 1, 1981, to Aug 15, 1987, was performed. During this time, 751 biopsies were performed on patients aged 9 to 40 years. None of the 128 patients aged 20 years or less had carcinoma. Of 150 patients aged 21 to 25 years, two had carcinoma. At age 26, there began a steady rise in the incidence of carcinoma, such that in the 36- to 40-year age group, carcinoma was present in 24.4% of the specimens. This retrospective review confirms previous reports that suggest that carcinoma of the breast is distinctly unusual in patients under age 20 and that breast masses in these young patients should be managed conservatively. As the incidence of carcinoma increases with the age of the patient, one's threshold for excisional biopsy should decrease.
为了更好地界定年轻患者患乳腺癌的风险,我们对1981年12月1日至1987年8月15日期间亚特兰大格雷迪纪念医院40岁以下女性的所有乳腺活检进行了回顾性研究。在此期间,对9至40岁的患者进行了751次活检。128名20岁及以下的患者均未患癌。150名21至25岁的患者中,有两人患癌。26岁时,癌症发病率开始稳步上升,在36至40岁年龄组中,24.4%的标本存在癌症。这项回顾性研究证实了先前的报告,即20岁以下患者患乳腺癌明显不常见,这些年轻患者的乳腺肿块应保守处理。随着患者年龄的增长,癌症发病率增加,进行切除活检的阈值应降低。