Watanabe A M, Green F, Ahmad Z
Department of Medicine, Indiana University School of Medicine.
Basic Res Cardiol. 1989;84 Suppl 1:19-22. doi: 10.1007/BF02650343.
We have reviewed the mechanism by which drugs that elevate cyclic AMP level modify myocardial contractility. We have presented preliminary evidence about the mechanism by which muscarinic agonists antagonize the effects of these drugs. Finally, we suggest that the protein phosphorylation experiments, particularly if done in dispersed myocytes, could be an efficient and cost-effective method of screening drugs which may act by elevating intracellular levels of cyclic AMP.
我们已经回顾了提高环磷酸腺苷（cAMP）水平的药物改变心肌收缩力的机制。我们已经给出了关于毒蕈碱激动剂拮抗这些药物作用机制的初步证据。最后，我们认为蛋白质磷酸化实验，特别是在分离的心肌细胞中进行的实验，可能是一种高效且经济有效的筛选药物的方法，这些药物可能通过提高细胞内环磷酸腺苷水平起作用。
