心房利钠因子对豚鼠小肠胆碱能及非肾上腺素能、非胆碱能神经传递的抑制作用。

Inhibitory action of atrial natriuretic factor on cholinergic and nonadrenergic, noncholinergic neurotransmission in guinea pig small intestine.

作者信息

Matusak O, Kuchel O

机构信息

Clinical Research Institute of Montreal, Quebec, Canada.

出版信息

Biochem Biophys Res Commun. 1989 Oct 31;164(2):638-44. doi: 10.1016/0006-291x(89)91508-8.

DOI:10.1016/0006-291x(89)91508-8

PMID:2554897

Abstract

We studied the effect of synthetic rat atrial natriuretic factor (ANF) (Ser 99-Tyr 126) on the isolated guinea pig proximal ileum. This preparation contained about one-third of the endogenous tissue ANF content which, for the most part, comes from the blood. ANF inhibited, in a dose-dependent manner, cholinergic twitch contractions (EC50 = 4.2 nM), nonadrenergic, noncholinergic (NANC) primary and rebound contractions and histamine-induced sustained tonic contraction (but not carbachol induced contraction) of the longitudinal muscle. Ascending enteric reflex (AER) contractions of the circular muscle were inhibited though not dose-dependently. We suggest pre- and post-synaptic actions of sustained intestinal tissue and blood ANF levels which may play a role in regulating motor activity and muscle tone of the small intestine.

摘要

我们研究了合成大鼠心房利钠因子（ANF）（Ser 99-Tyr 126）对离体豚鼠近端回肠的作用。该制剂含有约三分之一的内源性组织ANF含量，其中大部分来自血液。ANF以剂量依赖性方式抑制胆碱能抽搐收缩（EC50 = 4.2 nM）、非肾上腺素能、非胆碱能（NANC）原发性和反弹收缩以及组胺诱导的纵肌持续性强直收缩（但不抑制卡巴胆碱诱导的收缩）。环肌的升结肠反射（AER）收缩受到抑制，尽管不是剂量依赖性的。我们认为，持续的肠道组织和血液ANF水平的突触前和突触后作用可能在调节小肠的运动活性和肌张力方面发挥作用。