Zhang G H, Kraus-Friedmann N
Department of Physiology and Cell Biology, University of Texas Health Science Center, School of Medicine, Houston 77225.
Biochem Int. 1989 Aug;19(2):333-43.
It is demonstrated that the hepatic microsomal fraction contains significant adenylate-kinase activity. This explains a paradoxical ADP-stimulated Ca2+ uptake into microsomal vesicles which is inhibited when adenylate kinase is inhibited. The presence of adenylate kinase in the microsomal fraction helps to prevent sudden drops in ATP level, and thus has a stabilizing effect on the many ATP-dependent reactions carried out in this subcellular compartment.
已证明肝微粒体部分含有显著的腺苷酸激酶活性。这解释了一个矛盾现象，即微粒体囊泡中ADP刺激的Ca2+摄取在腺苷酸激酶被抑制时会受到抑制。微粒体部分中腺苷酸激酶的存在有助于防止ATP水平突然下降，因此对在这个亚细胞区室中进行的许多依赖ATP的反应具有稳定作用。
