Fitzpatrick Brendan, Woods Michael, Lynch Gordon, Manton David
University of Melbourne, Oral and Maxillofacial Surgery, Royal Melbourne Hospital, Australia.
Aust Orthod J. 2014 Nov;30(2):161-8.
To identify and demonstrate possible alterations of skeletal structures which might follow either unilateral surgical denervation of the masseter muscle, unilateral intramuscular injection of formoterol directly into the masseter muscle, or intramuscular formoterol injection after surgical denervation.
Male Sprague Dawley rats (N = 16; four weeks of age) were prepared as four groups: 1. surgical sham + saline injection into the masseter muscle (sham); 2. surgical denervation of the masseter muscle only (den.); 3. surgical denervation of the masseter muscle plus intramuscular formoterol injection into the affected muscle (den.+form.); 4. intramuscular formoterol injection into the masseter muscle only (form.). The specimens were submitted for CT examination, the skulls and hemimandibles were photographed and measurements of craniofacial bones were made.
In this relatively small sample, comparisons between non-experimental and experimental sides revealed differences, both within the groups and for the same measurements between groups, with the den. and den.+form. groups showing the most change. Relative increases in the gonial angle shown in these groups occurred bilaterally, with the change on the experimental side always greater in magnitude than the change on the contralateral side.
Surgical denervation of the masseter muscle leads to an alteration in the size and shape of the skeletal structures close to the zygoma and the mandible. The intramuscular injection of formoterol into denervated masseter muscle seems to limit this skeletal alteration after surgical denervation.
识别并证明在进行咬肌单侧手术去神经支配、将福莫特罗直接单侧肌内注射到咬肌中或手术去神经支配后进行肌内注射福莫特罗后，骨骼结构可能发生的改变。
将雄性斯普拉格-道利大鼠（N = 16；4周龄）分为四组：1. 手术假操作 + 向咬肌注射生理盐水（假手术组）；2. 仅对咬肌进行手术去神经支配（去神经组）；3. 对咬肌进行手术去神经支配并向患侧肌肉肌内注射福莫特罗（去神经 + 福莫特罗组）；4. 仅向咬肌肌内注射福莫特罗（福莫特罗组）。将标本送去进行CT检查，拍摄颅骨和半侧下颌骨照片，并对颅面骨进行测量。
在这个相对较小的样本中，非实验组和实验组之间的比较显示，组内以及组间相同测量值均存在差异，去神经组和去神经 + 福莫特罗组变化最大。这些组中显示的下颌角相对增加双侧均有发生，实验侧的变化幅度总是大于对侧。
咬肌的手术去神经支配会导致靠近颧骨和下颌骨的骨骼结构的大小和形状发生改变。在去神经的咬肌中肌内注射福莫特罗似乎可以限制手术去神经支配后的这种骨骼改变。
