Nikoo Mohammad Hossein, Taghavian Seyed Rahmatollah, Golmoghaddam Hossein, Arandi Narges, Abdi Ardakani Alireza, Doroudchi Mehrnoosh
Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Immunol. 2014 Dec;11(4):246-58.
Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known.
To compare IL-17A between patients with different types of AF and healthy individuals.
IL-17A was measured in sera of 112 patients and 107 healthy age/sex-matched controls using ELISA assay. In sera of 26 patients with elevated IL-17A (>1 Pg/ml), CCL5 and CCL18 levels were also measured.
IL-17A was significantly increased in patients with AF compared to controls (1.28 ± 3.5 vs. 0.19 ± 0.64 Pg/ml, p=0.001). There was no significant difference in the level of IL-17A between different types of AF. IL-17A was significantly higher in patients with a history of coronary artery bypass graft compared to other patients (p=0.01). A significant positive correlation between IL-17A and CCL18 concentration was found (p=0.001). An increase in the Neutrophil/Lymphocyte ratio (NLR) was observed in patients with elevated serum IL-17A compared to other patients (p=0.006). Male patients showed higher increase in NLR (p=0.007) which was accompanied by a decrease in CCL5 (p=0.000) and a marginal increase in CCL18 (p=0.085) compared to females. There was an increase in CCL5 levels in patients receiving Acetylsalicylic Acid (ASA) therapy (p=0.046).
The increase in IL-17A levels is related to the AF pathology mediated by neutrophils and monocytes. The current study signifies the role of immune cells and cytokines in the pathology of AF.
心房颤动（AF）是最常见的心律失常，也是老年人中风的独立危险因素。炎症在心房重构以及AF的发生和复发中所起的作用已为人所知。
比较不同类型AF患者与健康个体之间的白细胞介素-17A（IL-17A）水平。
采用酶联免疫吸附测定（ELISA）法检测112例患者和107例年龄/性别匹配的健康对照者血清中的IL-17A。在26例IL-17A升高（>1Pg/ml）的患者血清中，还检测了趋化因子配体5（CCL5）和趋化因子配体18（CCL18）水平。
与对照组相比，AF患者的IL-17A显著升高（1.28±3.5 vs. 0.19±0.64Pg/ml，p=0.001）。不同类型AF之间的IL-17A水平无显著差异。有冠状动脉搭桥术病史的患者的IL-17A显著高于其他患者（p=0.01）。发现IL-17A与CCL18浓度之间存在显著正相关（p=0.001）。与其他患者相比，血清IL-17A升高的患者中性粒细胞/淋巴细胞比值（NLR）增加（p=0.006）。男性患者的NLR升高更明显（p=0.007），与女性相比，CCL5降低（p=0.000），CCL18略有升高（p=0.085）。接受乙酰水杨酸（ASA）治疗的患者CCL5水平升高（p=0.046）。
IL-17A水平升高与中性粒细胞和单核细胞介导的AF病理过程有关。本研究表明免疫细胞和细胞因子在AF病理过程中的作用。
