青光眼患者房水和血清中可溶性MICA及MICB的浓度。
Aqueous humor and serum concentrations of soluble MICA and MICB in glaucoma patients.
作者信息
Nowroozpoor-Dailami Kiomars, Mirabi Araz-Mohammad, Tehrani Mohsen, Ajami Abolghasem
机构信息
Department of Ophthalmology, Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran, e-mail:
出版信息
Iran J Immunol. 2014 Dec;11(4):275-81.
BACKGROUND
Immune reactions have been reported to be involved in the destruction of retinal ganglion cells (RGCs) in glaucoma.
OBJECTIVE
To investigate the role of major histocompatibility complex class I-related chain A and B (MICA and MICB) molecules in the pathogenesis of glaucoma.
METHODS
Aqueous humor and serum samples from 15 glaucoma patients and 45 patients with cataract, undergoing ocular surgery, were obtained. The concentrations of MICA and MICB molecules in all samples were measured using ELISA.
RESULTS
Both MICA and MICB concentrations were higher in the aqueous humor of patients with glaucoma compared to those with cataract (p=0.013 and p=0.004, respectively); however, in the serum samples, no significant differences were observed.
CONCLUSIONS
Increased intraocular pressure may be associated with increased expression of the MICA and MICB molecules, which could initiate the destruction of RGCs and consequent development of glaucoma.
背景
据报道，免疫反应参与了青光眼患者视网膜神经节细胞（RGCs）的破坏过程。
目的
探讨主要组织相容性复合体I类相关链A和B（MICA和MICB）分子在青光眼发病机制中的作用。
方法
收集15例青光眼患者和45例接受眼科手术的白内障患者的房水和血清样本。采用酶联免疫吸附测定法（ELISA）检测所有样本中MICA和MICB分子的浓度。
结果
与白内障患者相比，青光眼患者房水中MICA和MICB的浓度均更高（分别为p=0.013和p=0.004）；然而，血清样本中未观察到显著差异。
结论
眼压升高可能与MICA和MICB分子表达增加有关，这可能引发RGCs的破坏及随后青光眼的发生。
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