Ridha Zainab, Quinn Rakesh, Croaker Geoffrey David Hain
The Australian National University, Canberra, Australia.
Pediatr Surg Int. 2015 Feb;31(2):137-42. doi: 10.1007/s00383-014-3651-2. Epub 2014 Dec 31.
Slow transit constipation (STC) and functional fecal retention (FFR) are two forms of severe intractable constipation in childhood diagnosed by nuclear transit studies (NTS). This retrospective study aims to identify the predicting factors for STC and FFR by looking at the association with neuropsychiatric disorders (NPD), obesity, family history of constipation and atopic disease.
A retrospective chart review was conducted on children with intractable constipation referred for NTS between 1st April 2003 and 1st April 2014. Comparisons were made between STC, FFR and normal transit patients with regards to NPD, obesity (BMI z score >95th percentile), family history of constipation in first and second-degree relatives and atopic disease which included food allergy, asthma and eczema.
Between 2003 and 2014, 97 patients were referred for a NTS. Out of 36 patients with NPD, 21 (58.3 %) had STC and 13 (36.1 %) had FFR (p < 0.05). 15.8 % of patients with constipation were obese, compared to 6.4 % in the general Australian paediatric population (p < 0.05). There was no significant association between constipation and atopic disease or family history.
Neuropsychiatric disorders, in particular autism, are useful predictors of STC and FFR in children. Obesity may be associated with a higher risk of developing chronic constipation.
通过核转运研究（NTS）诊断，慢传输型便秘（STC）和功能性粪便潴留（FFR）是儿童严重难治性便秘的两种形式。本回顾性研究旨在通过观察与神经精神疾病（NPD）、肥胖、便秘家族史和特应性疾病的关联，确定STC和FFR的预测因素。
对2003年4月1日至2014年4月1日期间因难治性便秘转诊进行NTS的儿童进行回顾性病历审查。比较了STC、FFR和正常转运患者在NPD、肥胖（BMI z评分>第95百分位数）、一级和二级亲属便秘家族史以及包括食物过敏、哮喘和湿疹在内的特应性疾病方面的情况。
2003年至2014年期间，97例患者转诊进行NTS。在36例患有NPD的患者中，21例（58.3%）患有STC，13例（36.1%）患有FFR（p<0.05）。便秘患者中有15.8%肥胖，而澳大利亚普通儿科人群中这一比例为6.4%（p<0.05）。便秘与特应性疾病或家族史之间无显著关联。
神经精神疾病，尤其是自闭症，是儿童STC和FFR的有用预测指标。肥胖可能与慢性便秘的较高发病风险相关。
