血小板压积能否作为复发性流产的一个标志物？
Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?
作者信息
Aynıoglu Oner, Isık Hatice, Sahbaz Ahmet, Harma Mehmet I, Isık Metin, Kokturk Furuzan
机构信息
Department of Gynecology and Obstetrics, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
Department of Gynecology and Obstetrics, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey
出版信息
Clin Appl Thromb Hemost. 2016 Jul;22(5):447-52. doi: 10.1177/1076029614565882. Epub 2014 Dec 29.
AIM
To determine the utility of platelet (PLT) indices for the prediction of recurrent pregnancy loss (RPL).
METHODS
In all, 208 patients who experienced 2 or more first trimester spontaneous abortions and 95 controls who had no abortions were studied. The hematological markers, including plateletcrit (PCT) and neutrophil (Neu) to lymphocyte (Lym) ratio (NLR), were measured. Thrombophilia genetic tests for factor V Leiden mutation, prothrombin G202I0A mutation, and methylenetetrahydrofolate reductase C677 T and A1298C mutations were performed.
RESULTS
The PLT count, PCT, white blood cell count, red cell distribution width (RDW), Lym and Neu count, and NLR were significantly higher in patients with RPL than in controls. The RDW, PLT, and PCT values were higher in the low-risk group, whereas mean PLT volume values were lower than the high-risk group values.
CONCLUSION
Plateletcrit is a low-cost, widely available marker for prediction of RPL in patients with a history of at least 1 abortus.
目的
确定血小板（PLT）指标对复发性流产（RPL）的预测效用。
方法
共研究了208例经历过2次或更多次孕早期自然流产的患者以及95例无流产史的对照者。测量了包括血小板压积（PCT）和中性粒细胞（Neu）与淋巴细胞（Lym）比值（NLR）在内的血液学指标。进行了因子V莱顿突变、凝血酶原G202I0A突变以及亚甲基四氢叶酸还原酶C677T和A1298C突变的血栓形成倾向基因检测。
结果
RPL患者的血小板计数、PCT、白细胞计数、红细胞分布宽度（RDW）、淋巴细胞和中性粒细胞计数以及NLR均显著高于对照组。低风险组的RDW、血小板和PCT值较高，而平均血小板体积值低于高风险组。
结论
对于有至少1次流产史的患者，血小板压积是一种低成本、广泛可用的预测RPL的指标。
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